c-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated (termed c-JunAA) can survive.
7 comments:
当学术领导的一个重要的能力是:
听报告睡着了后,醒来还能问出有意义的问题。
欢迎来访!
也许人家有睡梦中听报告的本领...
目标明确往上爬不算什么,没有实际好处(快退休了也无处可上)还要积极奋斗,我真服了...
不客气。
就一个问题:
你这 id 是那个 oncogene 么?
不是。oncogene 是谁?
Symbols: JUN; AP1; c-Jun
Aliases & Descriptions
jun proto-oncogene
c-Jun is the name of a gene and protein that, in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-Jun knockout is lethal, but transgenic animals with a mutated c-Jun that cannot be phosphorylated (termed c-JunAA) can survive.
咦?说起来这个oncogene我倒是有所耳闻,说不定是跟我同名的某科学家发现而命名的。
French accent is very sexy. Watch Before Sunrise.
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